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BP: Fachverband Biologische Physik

BP 7: Posters: Cell adhesion, mechanics and migration

BP 7.23: Poster

Monday, March 31, 2014, 17:30–19:30, P3

Migration behavior of human mesenchymal stem cells on biomimetic elastic substrates — •Daniel Meyer and Florian Rehfeldt — 3rd Institute of Physics - Biophysics, Georg-August University, Göttingen, Germany

Cell motility and migration processes are vital during biological development but also homeostasis. They are essential in tissue regeneration, morphogenesis, but also in pathological mechanisms like tumor metastasis. While migration due to biochemical gradients (e.g. chemotaxis) is very well studied, the influence of other parameters of the micro-environment such as topography and stiffness are less understood.

Nowadays, it is a widely appreciated fact that the mechanical properties of the matrix are significant factors for cellular processes. Here, we use polyacrylamide (PA) substrates with well-controlled Young*s moduli E and distinct biochemical composition of ECM ligands to mimic in vivo microenvironments and analyze the migration behavior of human mesenchymal stem cells (hMSC) by life cell microscopy.