Dresden 2014 – scientific programme
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BP: Fachverband Biologische Physik
BP 7: Posters: Cell adhesion, mechanics and migration
BP 7.45: Poster
Monday, March 31, 2014, 17:30–19:30, P3
Mechanical properties of human neutrophils in sepsis — •Maik Herbig1, Andrew Ekpenyong1, Leon Menschner2, Nicole Töpfner2, Li Wenlong1, Reinhard Berner2, and Jochen Guck1,3 — 1Biotechnology Center, Technische Universität Dresden, 01307 Dresden, Germany — 2University Hospital Carl Gustav Carus, 01304 Dresden, Germany — 3Cavendish Laboratory, Dept. of Physics, Univ. of Cambridge, CB3 0HE, UK
Recent studies have suggested the use of cell mechanical properties as a diagnostic marker for cancer. Similar use in infectious diseases has received considerably less attention. Using an optical stretcher we have measured the mechanical properties of neutrophils during infection by various sepsis-inducing bacteria. Tractable alterations in cell mechanics due to pathogens could engender its use as a diagnostic marker for sepsis. Furthermore, our work may offer new insights into the complex interactions between immune cells and pathogens.