Dresden 2014 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 7: Posters: Cell adhesion, mechanics and migration

BP 7.46: Poster

Montag, 31. März 2014, 17:30–19:30, P3

Shape fluctuations and osmotic pressure in rounded fibroblasts — •Samaneh Rezvani and Christoph Schmidt — Drittes Physikalisches Institut - Biophysik, Georg-August-Universität Göttingen, Germany

The structure of the cytoskeleton is complex and controls a broad variety of dynamical behaviors.Oscillatory dynamics observed in certain cell types, most prominently in muscle cells such as, insect flight muscle cells which have evolved to generate rhythmic and rapid contractile forces.

Fibroblasts are the most common cells of connective tissue in animals and play an important role, for example, in wound healing. Shape studies of non-adhering rounded fibroblast cells showed a slow oscillatory behavior that can last many hours at a constant frequency.

Here, we further investigate periodic oscillations of 3T3 fibroblast cells in order to establish the driving forces. Using confocal microscopy, we follow the oscillation frequencies under controlled osmotic conditions in 3D.