Dresden 2014 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 7: Posters: Cell adhesion, mechanics and migration
BP 7.49: Poster
Montag, 31. März 2014, 17:30–19:30, P3
The interplay between the mechanical properties of viral fibers and the strength of virus-host links during early infection stages — •Pablo Ares1,2,3, Carmela García-Doval4, Aida Llauró2,3, Julio Gómez-Herrero2,3, Mark J van Raaij4, and Pedro J de Pablo2,3 — 1Nanotec Electrónica S.L., Tres Cantos (Madrid), Spain — 2Dpto. Física de la Materia Condensada - Universidad Autónoma de Madrid, Madrid, Spain — 3IFIMAC, Centro de Investigación de Física de la Materia Condensada, Madrid, Spain — 4Departamento de Estructuras de Macromoléculas, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
Viral fibers play a central role in many virus infection mechanisms since they recognize the corresponding host and establish a mechanical link on its surface [1]. Biochemical data indicate that in T4 bacteriophage, at least three of these fibers are required for initial host cell interaction, but do not reveal why three and no other number.
By using Atomic Force Microscopy [2] we obtained high-resolution images of gp37 fibers adsorbed on mica substrate in vitro, and probed their mechanical properties [3]. We hypothesize that three viral fibers provide enough mechanical strength to prevent a T4 virus from being detached from the bacteria by the viral particle Brownian motion.