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BP: Fachverband Biologische Physik
BP 8: Posters: Active cell and tissue mechanics
BP 8.3: Poster
Montag, 31. März 2014, 17:30–19:30, P3
Broken detailed balance: A tool for identifying non-equilibrium dynamics — •Christopher Battle1,4, Nikta Fakhri1,4, Chase Broedersz2,4, Fred C. MacKintosh3, and Christoph F. Schmidt1 — 1Drittes Physikalisches Institut, Georg-August-Universität Göttingen, Göttingen, Germany — 2Lewis-Sigler Institute for Integrative Genomics and Department of Physics, Princeton University, Princeton, NJ, USA — 3Dept. of Physics & Astronomy, Vrije Universiteit, Amsterdam, Netherlands — 4These authors contributed equally to this work
Living systems exist far from thermal equilibrium, with active processes undergirding many of their functions. While some cellular processes show unmistakable non-equilibrium characteristics, e.g. persistent directed motion, others are more subtle, exhibiting non-thermal, random motion which is similar in appearance to Brownian motion, e.g. cortical stress fluctuations or active cellular mixing. Some techniques such as combined active and passive microrheology can quantify the non-equilibrium component of such processes, but they require comparisons between different measurement modalities. We here present an alternative and very general technique to identify non-equilibrium processes, searching for violations of detailed balance in an appropriately chosen phase space of the system. Our approach has the advantage of not requiring comparisons between different measurement techniques, and also allows us to determine a lower limit on the work dissipated by an active system.