Dresden 2014 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 11: Interfaces and Thin Films I

CPP 11.8: Talk

Monday, March 31, 2014, 18:15–18:30, ZEU 114

Perfluorinated compound rigidifies model lipid membrane — •Beate-Annette Brüning¹ and Bela Farago² — ¹Soft Matter and Functional Materials, Helmholtz Zentrum Berlin, Berlin, Germany — ²Time-of-Flight and High Resolution, Institut Laue-Langevin, Grenoble, France

We report a combined dynamic light scattering (DLS) and neutron spin-echo (NSE) study on vesicles composed of the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC) under the influence of varying amounts of perfluorooctanoic acid (PFOA). Mechanical properties of a model membrane and the corresponding bilayer undulation dynamics can be specifically influenced by changing its composition. We have performed DLS on vesicles composed of DMPC/PFOA mixtures to investigate changes in their respective size and corresponding center-of-mass diffusion. We study bilayer undulation and bulk diffusion dynamics using NSE, on time scales up to 200 ns. We calculate the bilayer bending rigidities κ for varying ratios of the perfluorinated compound, and obtain a bilayer stiffening for increasing amounts of the perfluorinated surfactant. Similar to the effect evoked by cholesterol, we attribute the observed stiffening to a condensing effect of the perfluorinated compound on the lipid bilayer.