Dresden 2014 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 19: Poster Session 1 (joint session with BP)
CPP 19.7: Poster
Dienstag, 1. April 2014, 09:30–13:00, P1
Polymeric nanoparticles for drug delivery, stability and pH response — •Natalya Vishnevetskaya1, Margarita Dyakonova1, Anna Bogomolova2, Sergey Filippov2, and Christine Papadakis1 — 1TU München, Physikdepartment, Physik weicher Materie — 2Institute of Macromolecular Chemistry, Prague, Czech Republic
Polymer-drug conjugates based on the copolymer N-(2-hydroxypropyl) methacrylamide (HPMA) bearing the anticancer drug doxorubicin and a defined amount of hydrophobic moieties (cholesterol and its derivatives) are therapeutically highly potent. The structures of the pH cleavable cholesterol-HPMA linkage and of cholesterol itself influence on the nanoparticle formation and behavior in solution [1].
The micelle formation of various copolymers in phosphate buffer solution and their size was investigated using fluorescence correlation spectroscopy (FCS) by adding the fluorescence dye rhodamine 6G. We have compared the values of the hydrodynamic radii of the micelles and the critical micelle concentrations in very dilute solutions (as in blood) of the copolymers as well as the kinetics during time and pH changes. Using dynamic light scattering, the average size of the nanoparticles and their stability in various environments are studied, and (time-resolved) small-angle neutron scattering provides detailed information on the micellar core-shell structures.
[1] S.K. Filippov et al., Biomacromolecules 14, 4061 (2013)