Dresden 2014 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 35: Biomaterials and Biopolymers (joint session with BP) I

CPP 35.4: Vortrag

Mittwoch, 2. April 2014, 16:00–16:15, ZEU 222

Structural investigation of biomineralization processes in bio(mimetic)-materials by means of solid state NMR — •Anastasia Vyalikh and Ulrich Scheler — Leibniz-Institut für Polymerforschung Dresden e.V.

Solid state NMR is applied to study the structure of biominerals. While the 31P solid state NMR spectra of phosphate containing materials represent a single broad line resulting from the diversity of structural motives, 2D heteronuclear correlation (HETCOR) experiments provide signal separation, and therefore can be used to determine the nature of mineral phases and interfacial organic-inorganic structures. The structure formation of biomimetic apatite-gelatine nanocomposites has been revealed, demonstrating the interaction of mineral domains with the organic matrix in the intergrowth region. HETCOR NMR provides resolution for the identification of different phosphate minerals at very early mineralization stages, which do not yet result in crystallite particles visible in imaging and diffraction techniques. The development of different calcium phosphate species in newly formed tissues has been demonstrated, when dental model implants were inserted in the mandible of minipigs and extracted after various healing time. While in mature bone hydroxyapatite, amorphous calcium phosphate and octacalcium phosphate are observed, the earlier stages include in addition ß-tricalcium phosphate and brushite-like structures. We propose a method, which offers identification of biomineral components as well as the information on crystallite dimensionality based on strength of hydrogen bonds in water related structures.