Dresden 2014 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 52: Biomaterials and Biopolymers (joint session with BP) II

CPP 52.7: Hauptvortrag

Donnerstag, 3. April 2014, 16:45–17:15, ZEU 222

Threading DNA through nanopores for biosensing applications — •Maria Fyta — Insitute for Computational Physics, University of Stuttgart

The use of nanopores to read-out in an ultra-fast and cheap way the information inherent in DNA is being intensively investigated the last two decades. A biomolecule, like DNA, in a salt solution is electrophoretically threaded through a nanometer sized pore altering the ionic current that flows through the pore. Simultaneously, measuring the transverse tunneling currents across the nanopore can possibly lead to distinguishable electronic signatures for each DNA unit. Here, we will review some of our work related with the statistical and dynamical characteristics of the translocation process and the ionic current through the pore as obtained through multiscale simulations. Using more accurate simulations we will then report on our attempts to optimize the nanopore. Our efforts are focused on proper functionalization of the nanopore in order to enhance the transverse ionic current for reading-out the genetic information in DNA.