Dresden 2014 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 54: Poster Session 3

CPP 54.80: Poster

Donnerstag, 3. April 2014, 15:00–19:00, P2

Controlled drug release using nanodiamonds as drug carriers — •Tran Minh Vu, Andrea Kurz, Anna Ermakova, Goutam Pramanik, Boris Naydenov, Yuzhou Wu, Tanja Weil, and Fedor Jelezko — University Ulm

We investigated the drug release of nanodiamond- Doxorubicin (ND-DOX) complexes in different pH. DOX is a chemotherapeutic against cancer cells, e.g. mammary or liver tumors. Using untreated DOX in order to kill cancer cells has two main problems: DOX also affects healthy cells and cancer cells can be resistant through drug efflux [1]. These problems can be overcome by using ND-DOX complexes [1]. Nanodiamonds are non- toxic [2], can move through membrane cells [2] and their surface can be functionalized making them able for drug delivery. Cancer cells have a lower pH environment compared to healthy cells, therefore we did a pH- sensitive experiment. We prepared a sample of ND-DOX in a solution at pH 7. With a standard confocal setup we performed fluorescence correlation spectroscopy (FCS) and determined the hydrodynamic radius r. We observed that by changing the pH of the ND-DOX solution from 7 to 5 the radius r=130 nm at pH=7 decreased to r=6 nm at pH=5. The fluorescence signal came from DOX (our NDs are non- fluorescent) thus indicated DOX release from the bigger ND-DOX complex. These measurements can be done time- dependent, respectively pH dependent leading to drug release time and the pH value which triggers the release. [1] Chow et al., Sci.Transl. Med. 3, 73ra21 [2] Chi-Cheng Fu et al., PNAS 104 (3) 727-732