Dresden 2014 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 41: Poster - Pattern/ Nonlinear Dyn./ Fluids/ Granular/ Critical Phen.
DY 41.7: Poster
Donnerstag, 3. April 2014, 17:00–19:00, P3
Functional connectivity of distant cortical regions: role of remote synchronization and network symmetry — •Philipp Hövel1,2 and Vesna Vuksanović1,2 — 1Technische Universität Berlin, Germany — 2Bernstein Center for Computational Neuroscience Berlin, Germany
We aim to reproduce resting-state functional-connectivity (FC) networks modeling (neural and BOLD) activity of the interacting cortical regions. We focus on the topology of the network interactions as a main ingredient of our model based on experimental data taking into account both anatomical and functional connectivity. Hence, important information about the presence/absence of direct neural connections within functionally connected nodes is included in the model. Controlling for direct neural links in functional networks allows us to test hypothesis that remote synchronization of the neural activity, arising from the underlying topology of the network interactions, accounts for the FC between distant cortical regions.
Using Kuramoto oscillators with frequencies in gamma frequency range, we explore emergence of the synchronization between pairs of the neural network nodes for different interactions topologies obtained via thresholds to the empirically derived FC matrix. We show that pronounced synchrony between nodes reflects symmetry of the coupling matrix, i.e., the strong overlap in the respective neighborhoods. We also illustrate that symmetry of the interactions drives remote nodes into synchronized activity and therefore plays central role in emergence of the functional connections between distant cortical regions.