Dresden 2014 – wissenschaftliches Programm

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SOE: Fachverband Physik sozio-ökonomischer Systeme

SOE 6: Poster Session

SOE 6.14: Poster

Montag, 31. März 2014, 18:00–20:00, P2

Boolean networks with veto functions — •Haleh Ebadi¹ and Konstantin Klemm² — ¹Bioinformatics, Institute for Computer Science, Leipzig University, Haertelstrasse 16-18, 04107 Leipzig, Germany — ²Department of Theoretical Chemistry, University of Vienna, Waehringerstrasse 17, 1090 Wien, Austria

Boolean networks are discrete dynamical systems for modeling regulation and signaling in living cells. We investigate a particular class of Boolean functions with inhibiting inputs exerting a veto (forced zero) on the output. We give analytical expressions for the sensitivity of these functions and provide evidence for their role in natural systems. In an intracellular signal transduction network [Helikar et al., PNAS (2008)], the functions with veto are over-represented by a factor exceeding the over-representation of threshold functions and canalyzing functions in the same system. In Boolean networks for control of the yeast cell cycle [Fangting Li et al., PNAS (2004), Davidich et al., PLoS One (2009)], none or minimal changes to the wiring diagrams are necessary to formulate their dynamics in terms of the veto functions introduced here.