Mainz 2014 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 1: Radiation Therapy & Dosimetry
ST 1.6: Vortrag
Montag, 24. März 2014, 18:00–18:15, RW 2
Development of a phantom for organs at risk dose studies using fluorescent nuclear track detectors in ion beam cancer therapy — •Tina Pfeiler1,2, Raya Gallas3, Armin Runz2, Mark Akselrod4, Oliver Jäkel2,5, and Steffen Greilich2 — 1Heinrich-Heine-University Düsseldorf, Department of Physics — 2German Cancer Research Center (DKFZ), Division of Medical Physics in Radiation Oncology — 3Ruprecht-Karls-University Heidelberg, Department of Physics and Astronomy — 4Landauer Inc., Stillwater Crystal Growth Division — 5Heidelberg Ion-Beam Therapy Center (HIT)
Ion beam cancer therapy provides a very localized energy deposition for the treatment of malignant tumors. A major challenge are uncertainties caused by organ motion and differential biological effects of secondary particles. Therefore, we investigate the feasibility of determining biological dose to organs at risk in vivo by fluorescent nuclear track detectors (FNTDs).
FNTDs consisting of C- and Mg-doped aluminum oxide crystals are small biocompatible detectors. Thus, they can be used in realistic phantoms or even in-vivo. Color centers in the FNTD undergo permanent radiochromatic transformations under ionizing radiation. The stored information is read out by a confocal laser-scanning microscope.
A phantom for the irradiation of liver carcinoma that hosts FNTDs as well as 3D dosimetry gel has been developed. It relies on our group experience in manufacturing gel based phantoms providing radiological properties. The current phantom mimics the liver, adipose tissue and breathing motion by movable ribs.