Berlin 2015 – scientific programme

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BP: Fachverband Biologische Physik

BP 15: Posters: Multi-cellular systems

BP 15.12: Poster

Monday, March 16, 2015, 17:30–19:30, Poster A

Glassy Dynamics in a Receptor Dynamics Model for Tumorigenesis — •Yuting Lou and Yu Chen — SCS Lab, Department of Human and Environmental Engineering, Graduate School of Frontier Science,University of Tokyo, Tokyo, Japan

A multi-cell receptor dynamics model for tumorigenesis is built for investigating the diversity of homeostasis and the origin of abnormal preneoplastic dynamics from a systematical perspective. Our simulations of cells growth and wound healing show the homeostasis state presents rich glassy dynamics such as diverse relaxation patterns from a wound perturbation, a large spectrum of relaxation timescale for reaching cell arrest, aging, and ergodicity breaking.The origin of the homeostatic diversity lies in these glassy dynamics whose characteristic timescales differs. Several parameters have been studied and the ability of cell arrest was found to be the role of control factor deciding the scale of the process. The size scale of the cell mass increase with the time scale of relaxation within which all cells reach its arrest state.Another simulation with the mechanism of genetic deficiency newly added to the receptor dynamics model, found that mutations help extend this scale in a normal homeostatic process.This dependency helps render a hypothesis: cancer happens when the system is undergoing glass transition where the relaxation time goes to infinity in terms of our observation timescale. This draw a unified picture for the initiation of benign tumor and cancer, and also explains the reason why these diseases feature long latency before exploding as well as the large spectrum of periods before they relapse.