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BP: Fachverband Biologische Physik

BP 16: Posters: Cell adhesion, mechanics and migration

BP 16.18: Poster

Montag, 16. März 2015, 17:30–19:30, Poster A

Examining the influence of size and shape of a particle on phagocytic uptake — Iris Kuntz, •Rebecca Michiels, and Alexander Rohrbach — Lab for Bio- and Nano-Photonics, University of Freiburg, Georges-Köhler-Allee 102, 79110 Freiburg, Germany

Phagocytosis is the process of a cell engulfing and uptaking a particle. This mechanism plays an important role in the functioning of our immune system. However, the influence of the particlessize and shape on the mechanisms and probability to uptake the particle is not clear yet.

We use a high-resolution light microscope equipped with optical tweezers and 3D interferometric particle tracking to induce phagocytic uptake of polystyrene micro-particles of different diameter. Using J774 mouse macrophages, we investigate the influence of variable contacting times and patterns until a defined response of the cell is measurable. First results are presented.