Berlin 2015 – scientific programme
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BP: Fachverband Biologische Physik
BP 19: Multi-cellular systems
BP 19.5: Talk
Tuesday, March 17, 2015, 10:45–11:00, H 1058
Towards the understanding of three-dimensional tissue organization — •Sebastian Ehrig1, Cécile M. Bidan2, Philip Kollmannsberger3, Peter Fratzl1, and John W. C. Dunlop1 — 1Max Planck Institute of Colloids and Interfaces, Germany — 2Université Joseph Fourier, Grenoble, France — 3Laboratory of Applied Mechanobiology, ETH Zürich, Switzerland
Biological materials possess an impressive range of mechanical properties due to their intrinsic tissue architecture. However, how these tissues organize to from complex three-dimensional structures over multi-cellular length scales is yet to be resolved. Using new theoretical approaches to self-organization along with 3D tissue culture experiments, we try to understand the dynamics of tissue-organization in 3D.
We recently demonstrated that tissue formation in straight sided pores of controlled shape can be described by a 2D model of curvature controlled growth as verified by subsequent experiments. Further advances in theoretical modeling enabled us to describe the spatial distribution of tissue growth in 3D.
We now develop active particle simulations on curved surfaces to explore the impact of 3D curvature on cell organization that give rise to the formation of complex tissue patterns. Insights into the design principles of the tissue and the role of the geometry of the surrounding environment on growth may have important consequences towards the understanding of tissue remodelling and scaffold design in tissue engineering.