Berlin 2015 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Posters: Statistical Physics of Biological Systems

BP 26.10: Poster

Dienstag, 17. März 2015, 14:00–16:00, Poster A

Statistical properties of Fisher's geometric model — •Sungmin Hwang, Ivan Szendro, and Joachim Krug — Insitute for Theoretical Physics, University of Cologne, Germany

Fisher's geometric model has played an important role for providing a connection between the phenotypic space and the fitness landscape while it remains simple enough to be analytically tractable. As complete or partial structures of fitness landscapes in many microbial organisms have been experimentally explored, the extensive effort has been made to understand the epistasis of the fitness landscape, i.e., the genetic interaction among mutations. In this work, we calculated the properties of epistasis distribution under various conditions in the frameworks of Fisher's geometric model. Especially, we focus on the case where the two single mutants have the same selection coefficient in order to analyze how epistasis varies in terms of the selection coefficient of the single mutants. Finally, we compare this result with experimental data to check the validity of our result.