Berlin 2015 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Posters: Statistical Physics of Biological Systems

BP 26.11: Poster

Dienstag, 17. März 2015, 14:00–16:00, Poster A

Theory of rapid force spectroscopy — •Jakob Tómas Bullerjahn, Sebastian Sturm, and Klaus Kroy — Universität Leipzig, Faculty of Physics & Earth Sciences, Institute for Theoretical Physics, Brüderstr. 16, 04103 Leipzig, Germany

Dynamic force spectroscopy allows the experimentalist to gauge the underlying free energy landscape of single molecular bonds by enforcing their rupture with external loading. At low loading rates, the experimentally measured distributions of rupture forces can be analysed using Kramers' theory of spontaneous unbinding, whereas the extreme forces observed in full-scale molecular simulations can be treated with deterministic methods. Starting from a rigorous probabilistic model of bond dynamics, we develop a unified systematic theory [1] that provides exact closed-form expressions for the rupture force distributions and mean unbinding forces, valid for all loading rates save for a narrow region close to a critical loading rate. Our results, in combination with Bayesian methods of data analysis, yield an accurate tool for analysing and comparing force spectroscopy data from a wide range of experiments and simulations.

[1] J. T. Bullerjahn, S. Sturm & K. Kroy, Nat. Comm. 5, 4463 (2014).