Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 26: Posters: Statistical Physics of Biological Systems
BP 26.13: Poster
Dienstag, 17. März 2015, 14:00–16:00, Poster A
Modeling chromosomes during meiosis in fission yeast — •Wenwen Huang1, Yen Ting Lin1, Daniela Frömberg1, Petrina Delivani2, Mariola Chacón2, Iva Tolic2, Frank Jülicher1, and Vasily Zaburdaev1 — 1Max Planck Institute for the Physics of Complex Systems, 01187, Dresden, Germany — 2Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany
During the prophase of meiosis in fission yeast, both ends of chromosomes are bound to the spindle pole body (SPB) and form a ring-like structure. Furthermore, the whole nucleus oscillates, moving from one pole of the zygote to the other. The dramatic movements of the nucleus are believed to promote the chromatin alignment and are required for proper recombination. Our goal is to understand the physical picture of chromosome alignment during nuclear oscillations. We perform extensive Brownian dynamics simulations of three pairs of homologous chromosomes during the oscillations. An individual chromosome is represented by a bead-rod ring, where the SPB is a special common bead shared by all the rings. A periodic force is applied to the SPB, which pulls the chromosomes through the viscous nucleoplasm and under the confinement of the cell walls. By setting parameters based on estimation of the available experimental data, we analyze the distance between the homologous loci as the function of time and amplitude of oscillations and compare it to the experimental data. Our results provide a quantitative characterization of of chromosome movements and help to understand the role of nuclear oscillations on the alignment of chromosomes during meiosis.