Berlin 2015 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Posters: Statistical Physics of Biological Systems

BP 26.7: Poster

Dienstag, 17. März 2015, 14:00–16:00, Poster A

Knotted protein folding as an ordered sequence of events — •Saeed Najafi and Raffaello Potestio — Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany

A small but relevant number of proteins whose native structure is known features nontrivial topology, i.e. they are knotted. Understanding the process of folding from a swollen conformation to the biologically-relevant conformation is, for these proteins, particularly difficult, due to the complex pathways leading to entangled state.To shed some light into this problem we introduced a native structure-based coarse-grained model of the protein, in which the information about the folded conformation is encoded in local, short-ranged interactions. Making use of a stochastic search scheme in the parameter space we can identify a set of interactions that maximize the folding probability to the native state.