Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 28: Posters: Biomaterials and Biopolymers
BP 28.5: Poster
Dienstag, 17. März 2015, 14:00–16:00, Poster A
A unified theoretical approach to the inelastic mechanics of biopolymer gels, cells and cell aggregates — •Andrea Kramer1, Matti Gralka2, and Klaus Kroy1 — 1Institute for Theoretical Physics, Universität Leipzig, Germany — 2Department of Physics, University of California, Berkeley, USA
Whereas classical viscoelastic models can often be applied to describe the mechanical response of biomaterials to small deformations, they cannot adequately be used to model the response to large deformations. Here, the transient breaking of bonds, e.g., crosslinks in biopolymer networks or cell-cell adhesions in cell aggregates, leads to a new class of response reminiscent of (pseudo-)plastic phenomenology.
We present a schematic modeling framework for the construction of inelastic models for biological materials based on the inelastic Glassy Wormlike Chain (iGWLC) model [1]. Decomposing the total deformation into viscoelastic and inelastic components, we provide a unified description that is able to qualitatively explain recent experimental data for the nonlinear mechanics of fibrin and collagen gels, cells and cell aggregates [2,3].
[1] L. Wolff et al., New J. Phys. 12, 053024 (2010)
[2] S. Münster et al., PNAS 110, 12197 (2013)
[3] T.V. Stirbat et al., Eur. Phys. J. E 36, 84 (2013)