Berlin 2015 – scientific programme

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BP: Fachverband Biologische Physik

BP 35: Membranes and vesicles II (joint BP/CPP)

BP 35.1: Invited Talk

Wednesday, March 18, 2015, 15:00–15:30, H 1028

Caged Hyperpolarized Xenon in Phospholipid Membranes for NMR Sensing Applications — •Leif Schröder — Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany

Spin-hyperpolarized xenon comes with high sensitivity and specificity for NMR spectroscopy due to the large chemical shift range of the dissolved gas. Recent developments in indirect detection of temporarily caged atoms through chemical exchange saturation transfer with hyperpolarized nuclei (Hyper-CEST) allows to sense for the molecular environment of the NMR-active isotope Xe-129 despite being a noble gas. In fact, its tendency to participate in labile van der Waals interactions facilitates very sensitive NMR detection. The hydrophobicity of xenon causes easy partitioning into phospholipid membranes where it can be combined with hydrophobic molecular cages as their hosts that confer a specific chemical shift to the guest nuclei for easy Hyper-CEST detection. The CEST effect is sensitive to exchange dynamics and can therefore be used to characterize the conditions for the specific host-guest system in various environments. This talk will give an overview about applications such as sensing for membrane fluidity and integrity or NMR imaging studies of liposome tracking for targeted drug delivery.