Berlin 2015 – scientific programme

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BP: Fachverband Biologische Physik

BP 5: Nanoparticles and Composite Materials I (joint CPP/BP)

BP 5.3: Talk

Monday, March 16, 2015, 10:00–10:15, C 243

A Toolbox to Connect the Physicochemical Properties of GNPs with their Biological Behavior — •Jonas Schubert and Munish Chanana — Department of Physical Chemistry II, University of Bayreuth, 95440 Bayreuth (Germany)

Due to their plasmonic properties and their biocompatibility gold nanoparticles (GNPs) are widely used in biological systems. Unfortunately, the colloidal variability is neglected in most studies, so that the chemical identity is not coherent with the biological identity. An undefined absorption alters the properties of the particles fundamentally, so that it is not possible to predict or study their biological behavior in dependence of their original physicochemical properties, e.g. surface charge.

To circumvent these problems, we present a toolbox of GNPs with a defined protein corona.[1,2] This defined protein corona enables the GNPs to meet the first requirement for biological applications: high colloidal stability in the presence of salt, other proteins and over a large range of pH values. A toolbox of more than 10 proteins and different purification procedures allow the exceptional chance of tailoring the physicochemical properties of nanoparticles, such as surface charge, colloidal stability and responsiveness.

1Chanana, M.; Correa-Duarte, M. A.; Liz-Marzan, L. M., Small 2011, 7 (18), 2650-2660.

2Chanana, M.; Gil, P. R.; Correa-Duarte, M. A.; Liz-Marzan, L. M.; Parak, W. J., Angewandte Chemie-International Edition 2013, 52 (15), 4179-4183.