Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 50: Biotechnology and bioengineering
BP 50.3: Vortrag
Donnerstag, 19. März 2015, 18:00–18:15, H 1058
Diamondoid-functionalized Au(111) nanoelectrodes as probes for detecting DNA and mutations — •Ganesh Sivaraman1, Rodrigo Garcia Amorim2, Ralph Scheicher2, and Maria Fyta1 — 1Institute For Computational Physics , University of Stuttgart, Germany — 2Division of Material Theory, Department of Physics and Astronomy, Uppsala University, Sweden
Solid state nanopores embedded with gold electrodes have been proposed to be strong candidates for the electrical read out of DNA . However, reduction in the noise in the electrical measurement is critical for an error free read out of DNA. A possible solution would be to use functionalized nanopores by which the specific interaction of a "functionalizing molecule" with the DNA should increase the signal-to-noise ratio in the measurements. Recently, we have proposed that amine and thiol doped diamond-like cages, known as diamondoids, as a candidate for functionalizing molecule .
In the first part of this theoretical investigation, we characterize the structure, electronic, and transport properties of Au(111) electrodes and diamondoid-functionalization on the Au(111) electrode surface. In the second part, a small bias voltage is applied across the Au(111) electrodes. The aim is to use the tunneling current across the functionalized junction as a means for distinguishing between individual DNA nucleobases/mutations. We will evaluate the tunneling current across the electrodes by inserting separately the 4 nucleotides, one mutant, and one epigenetic marker between the electrodes.