Berlin 2015 – scientific programme
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BP: Fachverband Biologische Physik
BP 8: Neurophysics II
BP 8.4: Talk
Monday, March 16, 2015, 15:15–15:30, H 1058
Spike timing reliability and information transfer under noisy juxtacellular stimulation --- Experiment and theory — •Jens Doose1,2, Guy Doron1,2, Michael Brecht1,2, and Benjamin Lindner1,2 — 1Bernstein Center for Computational Neuroscience — 2Humboldt University of Berlin, Berlin, Germany
We used nanostimulation, a technique which allows stimulation of identified single neurons in vivo, in order to drive pyramidal cells in anesthetized rat motor cortex. Using this method we find that stimulating with fluctuating stimuli (frozen bandpass-limited white noise) results in increased spike timing reliability. Specifically, we report that parametrically increasing the stimulus variance results in increased spike train synchronization. We also explore how well the spike train as well as statistics like the power spectrum or the spectral coherence function, in response to this stimulus can be captured by a model neuron. In particular we use the exponential integrate-and-fire neuron, a simple model that has been successfully applied for reproducing spike times of pyramidal cells under noisy current stimulation in vitro.