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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 43: P8: Nanoparticles and Compsite Materials
CPP 43.23: Poster
Mittwoch, 18. März 2015, 10:00–13:00, Poster A
Effective Interaction between globular, multivalent target-inhibitor-systems — •Susanne Liese1, Jonathan Vonnemann2, Daniel Lauster3, Sumati Bathia2, Andreas Herrmann3, Roland R. Netz2, and Rainer Haag1 — 1Freie Universität Berlin, Institut für theoretische Physik — 2Freie Universität Berlin, Institut für Chemie und Biochemie — 3Humboldt Universität zu Berlin, Institut für Biologie
Multivalency is an important design principle in nature. It is based on the simultaneous binding of several relatively weak binding partners, in order to strengthen the over-all interaction[1]. In our project we focus in on the interaction of globular, multivalent target-inhibitor-systems, as they are found in virus-inhibition-assays[2]. In these systems the target/inhibitor is evenly covered with receptor-/ligand-binding sites. The resulting interaction is influence by the collective binding of multiple receptor-ligand-pairs as well as by geometric shielding due to the extended size of target and inhibitor. We use a combination of coarse grained simulations and analytical methods to study the influence of the particle size, receptor/ligand-density and geometric shielding on the effective binding constant. [1] M. Mammen, S. Choi, G. M. Whitesides, Angew. Chem. Int. Ed. 1998, 37, 2754-2794 [2] I .Papp, C. Sieben, A.L. Sisson, J. Kostka, C. Böttcher, K. Ludwig, A. Herrmann, R. Haag, ChemBioChem 2011,12,887-895