Berlin 2015 – scientific programme
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DY: Fachverband Dynamik und Statistische Physik
DY 17: Modeling and Data Analysis
DY 17.9: Talk
Tuesday, March 17, 2015, 11:45–12:00, BH-N 333
Entropy maps of complex excitable dynamics in cardiac cell cultures — •Alexander Schlemmer1,2, T.K. Shajahan1, Sebastian Berg1,2, Stefan Luther1,2, and Ulrich Parlitz1,2 — 1Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17, 37077 Göttingen, Germany — 2Institute for Nonlinear Dynamics, Georg-August-Universität Göttingen, Am Fassberg 17, 37077 Göttingen, Germany
The characterization of spatiotemporal complexity remains a challenging task. This holds in particular for the analysis of data from fluorescence imaging (optical mapping), which allows for the measurement of membrane potential and intracellular calcium at high spatial and temporal resolution. Hitherto methods include dominant frequency maps and the analysis of phase singularities. While these methods address some important aspects of cardiac dynamics, however they only consider very specific properties of excitable media.
We implemented several information-theoretical quantities derived from symbolic chains and wavelet-spectra. Using optical mapping from embryonic chicken cell culture experiments the methods have been validated and benchmarked. We discuss our findings with respect to dominant frequency maps and analysis of phase singularities. In this context we present a workflow to preprocess, filter and analyse large amounts of video data using the above techniques.