Berlin 2015 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 59: Poster - networks

DY 59.7: Poster

Donnerstag, 19. März 2015, 16:00–18:00, Poster A

Topological and geometrical properties of mitochondrial networks — •Andreas Veres, Sven Bauernfeind, and Matthias Weiss — University of Bayreuth, Bayreuth, Germany

Mitochondria typically form extended networks in eukaryotic cells which span throughout the cytoplasm. It is commonly believed that network formation correlates with the cells energy demand, yet the basic physico-chemical self-organization processes that govern network formation and maintenance are poorly understood. Using live-cell imaging and quantitative image analysis we have studied topological and geometrical properties of mitochondrial networks in untreated cells and in cells lacking microtubules. In particular, we have quantified the network efficiency via the "node betweenness" and we have used a number-and-brightness analysis and quantitative bleaching experiments to estimate the local flux within mitochondrial tubes. In response to drug treatment, we observed gross changes in the organization of mitochondria. Based on our experimental data, we have formulated a quantitative simulation model that rationalizes the observed transition.