Berlin 2015 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 69: Complex Fluids and Soft Matter (joint session BP/DY/CPP)
DY 69.5: Vortrag
Freitag, 20. März 2015, 10:30–10:45, H 1058
Dynamics of biological membrane mimics - A combined QENS and MD simulation study — •Lisa Lautner1, Martin Schmiele1, Sebastian Busch2, Michaela Zamponi3, and Tobias Unruh1 — 1Chair for Crystallography and Structural Physics, FAU Erlangen-Nuremberg, Germany — 2University of Oxford, United Kingdom — 3Heinz Maier-Leibnitz Zentrum, Garching
Phospholipids are of high interest in the fields of biology and biophysics. As a main component of biological cell membranes the lipids are involved in lipid-lipid and lipid-protein interactions and therefore essential in a variety of cell functions. Many of these processes, e.g. binding to or transport through the membrane, are coupled to their structure and dynamics. Quasielastic Neutron Scattering (QENS) experiments and state-of-the-art Molecular Dynamics (MD) simulations yield a complementary view on these processes, with high spatial as well as temporal resolution.
A combination of QENS experiments and MD simulations was used to obtain a detailed understanding of the dynamics of biomimetic POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) bilayers in the liquid crystalline (L(α)) phase. Special emphasis was thereby the study of the temperature dependent behaviour of the phospholipid dynamics. The results of both the QENS experiments and the MD simulations coincide nicely and confirm the benefit of the combination of these complementary methods. These results provide a basis for extended studies on more complex systems e. g. lipid mixtures and lipid-protein interactions. First results of such experiments will be presented as well.