Berlin 2015 – scientific programme

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MM: Fachverband Metall- und Materialphysik

MM 50: Biomaterials and Biological Materials III

MM 50.2: Talk

Thursday, March 19, 2015, 10:45–11:00, TC 006

Response of rat bone structure and mineralization to a degrading Magnesium implant — Tilman Grünewald¹, Harald Rennhofer¹, Martin Meischel¹, Vicki Nue², Bernhard Hesse³, Manfred Burghammer³, Alessandra Gianoncelli⁴, Henrik Birkedal², Marine Cotte³, Annelie Weinberg⁵, Stefanie Stanzl-Tschegg¹, and •Helga Lichtenegger¹ — ¹Inst. of Physics and Materials Science, Univ Natural Resources and Life Sciences, Vienna, Austria — ²iNANO, University of Aarhus, Denmark — ³ESRF, Grenoble, France — ⁴Elettra Sincrotrone, Trieste, Italy — ⁵Dept. Orthopedics & Orthopedic Surgery, Med Univ Graz, Austria

Biodegradable bone implant materials are of special interest for medical application specifically in children, where traditional implants have to be removed in a second surgery in order not to disrupt bone growth. In this study we investigated the response of bone mineralization to a degradable Mg implant in a rat model (Sprague-Dawley rat) over a growth period from 1-18 months. Alterations in the bone nano- and mineral structure were investigated by synchrotron-based methods such as small-angle x-ray scattering (SAXS) and diffraction (XRD), x-ray fluorescence (XRF), as well as x-ray absorption spectroscopy (XAS) at a spatial resolution of about 3 micrometer. The combined study showed nanostructural changes at the interface to the degrading implant, but also changes in the bone mineral structure by the presence of Mg ions. Interestingly Mg enrichment was also found around blood vessels several hundreds of micrometer away from the bone-implant interface, which sheds light on possible Mg transport mechanisms.