Berlin 2015 – scientific programme

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MM: Fachverband Metall- und Materialphysik

MM 54: Biomaterials and Biological Materials IV

MM 54.2: Talk

Thursday, March 19, 2015, 12:00–12:15, TC 006

Understanding Macroscopic Interfacial interactions based on Single Molecule Energy Landscapes — Sangitha Raman, Thomas Utzig, Philipp Stock, and •Markus Valtiner — Max-Planck-Institut für Eisenforschung GmbH, Department for Interface Chemistry and Surface Engineering,D-40213 Düsseldorf, Germany

Understanding cell adhesion on metals and oxides, cell-cell interaction or interfaces in biomaterials based on single molecular level details relies on understanding the scaling of single molecule interactions towards integral interactions at the meso- and macroscopic scale. Here, we discuss how one can decipher the scaling of individual single acid-amine interactions towards the macroscopic level, where a large number of these bonds interacts simultaneously, using a synergistic experimental approach combining Surface Forces Apparatus (SFA) experiments and single molecule force spectroscopy (SMFS). We show that equilibrium SFA measurements scale linearly with the number density of acid-base bonds at an interface, providing acid-amine interaction energies of 10.9 ± 0.2 kT. SMFS similarly converges to an interaction energy of 11 ± 1 kT, with unbinding energy barriers of 25 kT ± 5 kT. Finally, we will also show how other specific adhesive bonds such as the Amine/Gold binding can be successfully studied in the contest of our approach. As such, our experimental strategy provides a unique framework for molecular design of novel functional materials through predicting of large-scale properties such as adhesion, self-assembly or cell-substrate interactions based on single molecule energy landscapes.