Berlin 2015 – wissenschaftliches Programm

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SYNP: Symposium Neurophysics: Physical Approaches to Deciphering Neuronal Information Processing

SYNP 1: Symposium Neurophysics (SYNP): Physical Approaches to Deciphering Neuronal Information Processing

SYNP 1.5: Hauptvortrag

Dienstag, 17. März 2015, 11:45–12:15, H 0105

Distributed neuro-physical interfaces: technology and "exciting" biophysics — •Shy Shoham — Dept. Biomedical Eng., Technion - I.I.T., Haifa, Israel

In addition to the widely-used ability to selectively target specific cell types, Optogenetics and other emerging strategies for remote stimulation also offer a path towards spatio-temporally-controlled targeting. For example, projected patterns of light can be used to selectively and flexibly control and image activity patterns distributed across entire populations of neurons.

The talk will present an overview of our recent work on distributed neuronal interfacing with large populations of neurons using optical and acoustic wavefront shaping approaches. Our results demonstrate that patterned computer-generated holographic stimulation can achieve millisecond temporal precision and cellular resolution in two-dimensions (retinas) and three dimensions (bioengineered brain-like "optonets") and are shown as a promising path towards simultaneously controlling populations of retinal ganglion cells in a next generation retinal prosthesis. I will conclude by discussing the emerging model-based Neural Intramembrane Cavitation Excitation (NICE) framework for elucidating the physical basis of neuro-acoustic excitation and some "exciting" insights it provides into this emerging technology for noninvasive neuromodulation.