Wuppertal 2015 – wissenschaftliches Programm

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ST: Fachverband Strahlen- und Medizinphysik

ST 1: Biomedical Imaging I

ST 1.9: Vortrag

Montag, 9. März 2015, 16:00–16:15, BZ.08.02 (HS 3)

Tissue decomposition using grating-based phase-contrast computed tomography (PC-CT) — •Manuel Viermetz, Lorenz Birnbacher, Marian Willner, Mathias Marschner, Julia Herzen, and Franz Pfeiffer — Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München

Talbot-Lau interferometry provides three complementary imaging modalities, the conventional attenuation contrast, the differential phase-contrast signal which has enhanced soft tissue contrast and the dark-field signal which is related to small angle sample scattering. This technique which is also available with laboratory X-ray sources in a setup consisting of three gratings is used for computed tomography for each of these modalities.

The ability to access the refractive index decrement and the linear attenuation coefficient in one registered measurement enables advanced evaluation methods of tissue properties. We focus on the quantitative tissue analysis based on the complementary attenuation and phase-contrast information to assess the fractions of lipid, protein and water in the sample. The concept of decomposition using PC-CT is evaluated for recently acquired imaging results of biomedical samples and phantoms.