Hamburg 2016 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 2: Biomedical Imaging I
ST 2.10: Vortrag
Dienstag, 1. März 2016, 16:00–16:15, VMP6 HS C
Highly-resolved structural analysis of arterial blood vessel walls in different stages of arteriosclerosis by magnetic resonance microscopy — •Marvin Heil1, Daniel Edelhoff1, Inge Schmitz2, and Dieter Suter1 — 1TU Dortmund Deutschland — 2Ruhr-Universität Bochum Deutschland
During the progress of cardiovascular diseases, the structural properties of blood vessel walls change, e.g. due to deposits of fat, cholesterol and other substances in and on the wall. For an improved understanding of the detailed processes leading to these changes, we examine pig and rat vessels at different stages of arteriosclerosis.
Using Magnetic Resonance Microscopy, we obtain highly resolved images of the structures present in the vessel walls and characterize their changes. We use a 14.1 MHz spectrometer and a homebuilt probe that providesa resolution of up to 10 µm. Different contrasts based on relaxation times are used to distinguish the vessel wall components and measure their anisotropic properties. We use 2D- and 3D imaging based on FLASH and Spin Echo sequences to visualize the hardening process of the vessel wall with special attention to the microstructural variations on the inner side of the vessel wall. The orientation of these microstructures depends on the blood flow and can thus help to detect pathological alterations.
In the future we plan to complement our MRI measurements with X-ray tomography to verify and compare our results.