Hamburg 2016 – scientific programme

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ST: Fachverband Strahlen- und Medizinphysik

ST 2: Biomedical Imaging I

ST 2.7: Talk

Tuesday, March 1, 2016, 15:15–15:30, VMP6 HS C

High-Resolution Imaging of Small Soft-Tissue Samples in Micro-CT — •Eva-Maria Braig¹, Kai Scherer¹, Christian Enders², Jens Werner², Gerhard Lang², Gabriele Lang², Julia Herzen¹, and Franz Pfeiffer¹ — ¹Technische Universität München, Garching — ²Universitätsklinikum Ulm, Ulm

X-ray imaging became a powerful and indispensable tool in medical diagnostics. While in-vivo applicability of a new imaging modality is always of high priority to maximize the medical benefit from new research results, ex-vivo or in vitro studies can offer an enlightening insight to basic biological processes. Without the restrictions of radiation dose and bio-compatibility new staining protocols in combination with micro-CT X-ray setups are capable of non-destructive three-dimensional high-resolution soft-tissue imaging. Here, we show the high-resolution image results of functional anatomical structures of a porcine eye. Additionally, it is presented, how a non-destructive technique, without any sample preparation can be included into clinical histology of a human eye. Comparison with the conventional histological image shows a high correlation with all histological findings and reveals even further diagnostic information. The reconstructed CT-data provides high-resolution detail-information in any arbitraryly directed volume slice, without geometrical distortion and without material loss. Subsequent histological investigations are not compromised by a preceding micro-CT measurement and the method is easily implementable into a clinical workflow.