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ST: Fachverband Strahlen- und Medizinphysik

ST 2: Biomedical Imaging I

ST 2.8: Vortrag

Dienstag, 1. März 2016, 15:30–15:45, VMP6 HS C

Quantitative analysis of staining protocols for X-ray micro tomography — •Ronja Berg¹, Madleen Busse¹, Marian Willner¹, Manuel Viermetz¹, Melanie Kimm², Alexander Fingerle², Ernst J. Rummeny², Franz Pfeiffer¹, and Julia Herzen¹ — ¹Physics Department & Institute for Medical Engineering, Technical University of Munich, Munich, Germany — ²Radiology Department, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany

The limited soft-tissue contrast of the conventional micro computed tomography (microCT) can be overcome by staining protocols, which are increasing the atomic number and thus the contrast in the specimen. While various staining protocols exist, their exact influence on different types of tissue is still unclear. This fact makes it difficult to choose the best staining for different soft tissues, as the contrast gain can hardly be predicted. In this work we aim at studying two different staining protocols for soft tissue - one based on iodine and one on eosin. The stained soft-tissue was imaged using commercial microCT and phase-contrast tomography, which provides complementary and quantitative information. The imaging results were analyzed quantitatively in terms of Hounsfield Units in both modalities and compared to histopathology.