Regensburg 2016 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 12: Single Molecule Biophysics

BP 12.4: Vortrag

Montag, 7. März 2016, 16:30–16:45, H45

Kinesin-1 motors throw each other off the microtubule — •Matthias Rank and Erwin Frey — Arnold Sommerfeld Center for Theoretical Physics (ASC) and Center for NanoScience (CeNS), Department of Physics, Ludwig-Maximilians-Universität München

Inside cells, a large number of molecular motors bind to microtubules (MTs) where they perform directed motion. While it is generally accepted that steric hindrance of motors leads to crowding effects, little is known about their specific interactions. We examine a variation of the totally asymmetric simple exclusion process with Langmuir kinetics (TASEP/LK), in which dissociation of molecular motors is enhanced on crowded filaments. We demonstrate that a two-particle ``throwing out'' interaction can explain recent experimental data for kinesin-1 excellently. Following a theoretical mean-field approach, we derive the phase diagram of the process for important limits. We further extend our results to motors of two different types, and propose an efficient mechanism how they can phase separate on the MT. This can be important for cellular processes requiring ongoing catalytic activity of a specific motor type, and motors which operate cooperatively.