Regensburg 2016 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 14: Posters - Biotechnology and Bioengineering

BP 14.1: Poster

Montag, 7. März 2016, 17:30–19:30, Poster C

Hydrodynamic Flow Control from Micro- to Picolitres — •Katja Prasol and Claus Fütterer — Biophysical Tools GmbH/Forschung, 04317 Leipzig, Germany

During the last decade biophysists, biochemists and biologists moved to microfluidics in their applications. Prokaryotic and eukaryotic cells are cultured and investigated in microfluidic chips, they are sorted in microfluidic systems, other molecules, even DNAs, are being observed in micro-droplets.

All of these applications are highly dependent on a precise flow control, which is conventionally done with syringe or peristaltic pumps. However, such approaches have a number of bottlenecks. Smallest irregularities in piston motion of syringe pumps are strongly hydrodynamically amplified in the flow velocity. The peristaltic pump, based on squeezing of tubing, does not allow precise determination of the perfused volume and generates strongly pulsatile flow.

Within our research we focused on the development and testing of novel pressure-driven flow control methods. Recently we developed a new pneumatic flow control principle. Our new system overcomes the bottlenecks of conventional flow control methods including the current state-of-the-art in microfluidic flow control (Fütterer et al., Injection and Flow Control in Microchannels, Lab Chip, 4, 351, 2004). Further, we present data on stability, fast dynamics as well as a number of real and future applications in biology, biophysics and medical research.