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BP: Fachverband Biologische Physik

BP 16: Posters - Computational Biophysics

BP 16.2: Poster

Montag, 7. März 2016, 17:30–19:30, Poster C

Structures and Processes in a Quantum Rattle — •Amanda Diez Fernandez, Molly Stevens, and Mike Finnis — Imperial College London, United Kingdom

Nanoparticles bring new possibilities to the field of drug delivery engineering. One of the properties nanoparticles for drug delivery must have is a large drug loading capacity and an extended and sustained release. This is necessary to ensure constant drug levels in the target tissue and improve drug efficiency. We recently developed a Quantum rattle based nanoparticle for drug loading and release [1] as well as multimodal imaging capabilities.

In order to understand the key features of the nanoparticle responsible for drug loading and release and to enable further optimisation of these parameters, we have taken a multiscale modelling approach. Firstly, a continuum mathematical model has been developed to describe drug diffusion and sorption in the nanoparticle. In the next phase of the project, Molecular Dynamics simulations are being done to obtain information from lower scales, such as the drug diffusion coefficient inside the pore channels.

REFERENCES:

[1] Gold silica quantum rattles for multimodal imaging and therapy M. Hembury, C. Chiappini, S Bertazzo, T. L. Kalberd, G. L. Driskoe, O. Ogunladed, S. Walker-Samueld, K.S. Krishnai, C. Jumeaux, P. Beard, C.S.S.R.Kumari, A. E. Porter, M.F.Lythgoe, C. Boissièree, C. Sanchez, and M. M. Stevens PNAS, February 17, 2015, vol. 112, no. 7, 1959 1964