Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 19: Posters - Membranes and Vesicles
BP 19.9: Poster
Montag, 7. März 2016, 17:30–19:30, Poster C
Hydration Interaction between phospholipid membranes in the presence of co-solutes — •Anirudh Gupta1, Alexander Schlaich1, Dat Pham2, Matej Kanduč3, Emanuel Schneck4, Emma Sparr2, and Roland R. Netz1 — 1Fachbereich Physik, Freie Universiät Berlin, 14195 Berlin, Germany — 2Physical Chemistry, Lund University, 22100 Lund, Sweden — 3Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin, 14109 Berlin, Germany — 4Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
We study the interaction between phospholipid bilayers across water in the presence of co-solutes, namely TMAO (Trimethylamine N-oxide) and urea. We investigate the interaction mechanisms and thermodynamics using atomistic simulations at prescribed water chemical potential. Our interaction pressures successfully reproduce experimental data, unveiling that the membranes become more repulsive due to addition of co-solutes, as also indicated by the experiments. TMAO acts as a stabilizer for proteins while urea acts as a denaturant. It is also well known that TMAO is repelled more from proteins than the urea molecules. Our results also indicate that TMAO molecules are repelled further away from the bilayer than urea; however, the effect of both co-solutes on the membrane interaction is similar.