Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 28: Systems Biology & Gene Expression and Signalling
BP 28.3: Vortrag
Dienstag, 8. März 2016, 10:15–10:30, H44
Control of single cell somitogenesis — •Jose Negrete JR1, Laurel Rohde2,3, Ravi Desai2,3, Andrew C. Oates2,3, and Frank Jülicher1 — 1Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — 2Francis Crick Institute, London, United Kingdom — 3University College London, United Kingdom
Embryo somitogenesis is preceded by the spatiotemporal evolution of a kinematic wave of cyclic genes such as her1. It is conjectured that this wave is at the same time modulated by the presence signaling gradients. In this work we have developed a theoretical formalism for analyzing the dynamics of her1 at the single cell level. Remarkably these cells show an oscillatory transient when they are disassociated from the embryo and positioned far from each other, suggesting that autonomous dynamics play an important role in somitogenesis. We have been able to identify the key parameters that are modulated during the evolution of her1 and from these we developed predictions that can be tested in experiment. In particular the parameters of the reaction rates of her1 are non-stationary suggesting that these are controlled by the signaling system.