Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 28: Systems Biology & Gene Expression and Signalling
BP 28.8: Vortrag
Dienstag, 8. März 2016, 12:15–12:30, H44
A coarse-grained growth control theory for growth transitions — •Severin Schink1, David Erickson2, Ulrich Gerland1, and Terence Hwa2, 3 — 1Physics of Complex Biosystems, Physics Department, Technical University of Munich, Germany — 2Department of Physics, University of California at San Diego, La Jolla, CA, USA — 3Section of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, USA
A grand challenge of systems biology is to predict the kinetic response of living systems following environmental perturbations. This task is typically approached in a bottom-up manner, by characterizing the temporal changes in gene expression patterns resulting from the applied perturbation, and deducing the underlying regulatory network. Progress towards quantitative predictive models has been limited however. A fundamental obstacle has to do with the large number of unknown interactions and parameters which vastly outnumber accessible data collected even by high-throughput methodology. In this study, we choose a top-down approach, based on phenomenological growth laws, previously developed for steady state growth. We extend these to the kinetic regime, and develop a coarse-grained flux-driven regulation theory to describe bacterial growth transitions and gene expression in response to transient nutrient changes. The theory is conceptually simple, analytically solvable, and captures the kinetics of bacterial growth transitions that occurs in response to nutrient up-shifts and down-shifts (also called diauxic shifts) quantitatively without free parameters.