Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 29: Multicellular Systems
BP 29.1: Hauptvortrag
Dienstag, 8. März 2016, 09:30–10:00, H45
Cell Migration in Confined Geometries — •Joachim O. Rädler1, Felix J. Segerer1, Anna-Kristina Marel1, Matthias L. Zorn1, Christoph Schreiber1, Peter Röttgermann1, Alexandra Fink1, Florian Thüroff2, and Erwin Frey2 — 1Faculty of Physics and Center for NanoScience Ludwig-Maximilians-Universität München — 2Arnold-Sommerfeld-Center for Theoretical Physics and Center for NanoScience, Faculty of Physics, Ludwig-Maximilians-Universität München
Epithelial cell migration is of prominent importance in wound healing, embryonic development, and cancer progression. Attempts to capture cellular hydrodynamics are currently progressing, yet it remains challenging to bridge multicellular motility to single cell migration. The talk intends to provide a perspective on how the study of cell migration in confining geometries facilitates and enhances the analysis of collective motility. Using time-lapse microscopy we study the directed flow of Madin Darby canine kidney (MDCK) cells in micro-channels. We also examine one of the hallmarks of active matter, the spontanenous emergence of vortices, in defined circular micropatterns with a fixed number of cells. The emergence of vortex states is reproduced by computer simulations based on a generalized Potts model. In agreement with experiment the model shows that vortex stability depends on the interplay of the spatial arrangement and internal polarization of neighboring cells. We will furthermore demonstrate that micropatterned surfaces allow the guidance of single cells and hence open up novel approaches to probe single-cell migration.