Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 29: Multicellular Systems
BP 29.2: Vortrag
Dienstag, 8. März 2016, 10:00–10:15, H45
Dynamics of model cell monolayers — •Damir Vurnek1, Sara Kaliman1, Carina Wollnik2, Florian Rehfeldt2, Diana Dudziak3, and Ana-Sunčana Smith1,4 — 1PULS group, Institute for Theoretical Physics I, FAU, Erlangen — 23rd institute of Physics - Biophysics, GAU, Göttingen — 3University Hospital, Erlangen — 4Division of Physical Chemistry, IRB, Zagreb
Morphogenesis and wound healing both require migration of a large number of constituent cells. This still unresolved problem of collective cell migration is addressed by using MDCK II model epithelium grown on collagen I coated glass substrates. We look at the global development of an initially droplet seeded system of cells which is allowed to expand freely over time. Large scale experiments spanning days and multiple connected fields of view are analyzed with particle image velocimetry of live fluorescent samples. This approach allows for both microscopic and macroscopic (millimeter) scales. As the whole edge, from the colony border up to the contact inhibited centre, is examined continuously new correlation length scales are uncovered. We analyze the connections between these scales and the perpetually increasing velocity of the colony border. Our recent findings push the limits of cooperative cell motion numbers into a previously unreported regime where thousands of cells act at the same time in a coordinated fashion.