Regensburg 2016 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 42: Biomaterials and Biopolymers I (Joint Session CPP/MM/BP)

BP 42.5: Vortrag

Mittwoch, 9. März 2016, 16:15–16:30, H40

Dynamic biointerfaces: new generation of cell instructive materials — •Chiara Fedele, Ravichandran H. Kollarigowda, Silvia Cavalli, and Paolo A. Netti — Center for Advanced Biomaterials for Healthcare, Istituto Italiano di Tecnologia, Neaples, Italy

Nowadays the growing interest in tissue engineering and biology for the in vitro control of cell fate has led to the design of dynamically actuable platforms through the implementation of stimuli-responsive materials in order to mimic the continuous remodeling of the extracellular matrix in living systems. Dynamic biointerfaces are conceived in order to be able to modify in a predictable spatiotemporal manner the cell-material crosstalk, overcoming the limitations of static conventional biomaterials. In our work, azobenzene-containing photosensitive polymers (e. g. polymer brushes, thin films, crosslinked free standing polymers) are designed as biomaterials to obtain patterned or reshaping substrates using photolithographic techniques or single laser beam instruments, in some cases even in presence of cells, allowing for a real-time modification of cell behavior.