Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 43: Cell Adhesion
BP 43.6: Vortrag
Mittwoch, 9. März 2016, 16:30–16:45, H43
The membrane as a matchmaker in the cell adhesion process — Timo Bihr1,2, Susanne Fenz3,4, •Daniel Schmidt1,2, Rudolf Merkel4, Kheya Sengupta5, Udo Seifert2, and Ana-Sunčana Smith1,6 — 1PULS Group, Inst. f. Theor. Physik and Excellence Cluster "Engineering of Advanced Materials", Universität Erlangen-Nürnberg — 2II. Inst. f. Theor. Physik, Universität Stuttgart — 3Department of Cell and Developmental Biology, Universität Würzburg — 4ICS 7: Biomechanics, Forschungszentrum Jülich — 5CNRS UPR 3118, CINaM, Aix-Marseille Université — 6Division of Physical Chemistry, Institute Ruđer Bošković, Zagreb
The integrity of living tissues is maintained by cadherin rich domains. Cadherin molecules form trans-dimers bridges between neighbouring cells. The formation of domains of trans-bonds is controlled by lateral, /in-plane/cis-interactions. The origin of these interactions are still debated. In this presentation, we show that the formation of cis-domains is regulated by the membrane via its elasticity and fluctuations. Observations from a cell free system consisting of cadherin-decorated model membranes show that the membrane regulates the trans-binding, and is itself a source of cis-interactions. We develop a theoretical framework to explicitly show that membrane fluctuations introduce complex cooperative effects that modulate the rates of binding and unbinding of the trans-dimers. The regulatory activity of the membrane, quantified here in the context of cadherins, relies purely on physical principles and therefore may be a generic player in the context of formation of any adhesion structures on the plasma membrane and in the cell interior.