Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 48: Posters - Bioimaging and Spectroscopy
BP 48.6: Poster
Mittwoch, 9. März 2016, 17:00–19:00, Poster C
Functionalization of Nanodiamond for the Use in Biophysics — •Frederike Erb1, Patrick Paul1, Fedor Jelezko2, and Kay-E. Gottschalk1 — 1Institute of Experimental Physics, Ulm University, Germany — 2Intstiute of Quantum Optics, Ulm University, Germany
Synthetic nanoparticles offer various new imaging and metrology approaches [3]. Of particular interest is the use of fluorescent nanodiamonds (FND) as markers for cell labeling. They contain negatively charged nitrogen-vacancy centers as fluorophores, whose emission lies in the near-infrared window of bioimaging and is dependent on the environment. Those nanodiamond markers are biocompatible and in contrast to dyes do neither blink nor bleach.
In order to prevent agglomeration and to offer specific binding the FNDs need to be functionalized [1], [2]. Here, we present preliminary results for our functionalization.
References: [1] Martin, R., Alvaro, M., Herance, J. R., Garcia, H. (2010). Fenton-treated functionalized diamond nanoparticles as gene delivery system. ACS Nano, 4(1), 65-74.
[2] Liang, Y., Ozawa, M., Krueger, A. (2009). A general procedure to functionalize agglomerating nanoparticles demonstrated on nanodiamond. ACS Nano, 3(8), 2288-2296.
[3] Chang, B. M., Lin, H. H., Su, L. J., Lin, W. D., Lin, R. J., Tzeng, Y. K., Lee, R. T., Yu, A. L., Chang, H. C. (2013). Highly fluorescent nanodiamonds protein-functionalized for cell labeling and targeting. Advanced Functional Materials, 23(46), 5737-5745.