Regensburg 2016 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 49: Posters - Cell Mechanics and Migration & Physics of Cancer

BP 49.10: Poster

Mittwoch, 9. März 2016, 17:00–19:00, Poster C

Mechanical coupling between the cytoskeleton and the nucleus — •Gabriele Straaß and Florian Rehfeldt — Third Physical Institute - Biophysics, Georg-August University, Göttingen

It is nowadays widely acknowledged that mechanical cues are as important for cellular behavior as traditional biochemical ones. Strikingly, adult stem cells can be guided to differentiate towards various cell types when cultured on elastic hydrogels with appropriate Young's modulus E. Here, the acto-myosin cytoskeleton organization shows significant differences within the first 24 hours after plating. We investigate the mechanical properties of the nucleus by atomic force microscopy and fluorescence microscopy and demonstrate the impact of substrate elasticity E on nuclear morphology and elasticity via acto-myosin stress fibers and other cytoskeletal filaments. Elucidating the mechanical coupling of the cytoskeleton and the nucleus might reveal a direct mechanical pathway that alters gene transcription and might impact adult stem cell differentiation.