Regensburg 2016 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 49: Posters - Cell Mechanics and Migration & Physics of Cancer

BP 49.5: Poster

Mittwoch, 9. März 2016, 17:00–19:00, Poster C

Development of a mechanically stable cell stretcher for measuring the influence of external strain on cell mechanics with the AFM. — •Fabian Port, Patrick Paul, and Kay-E. Gottschalk — Institute of Experimental Physics, Ulm University

The importance of cell mechanics on different physiological or pathophysiological conditions like stem cell differentiation [1] or cancer [2] is increasingly being recognized. Hence the knowledge of the mechanical properties of cells under varying conditions is crucial for understanding the underlying mechano-chemical feedback cycles. Importantly, the effect of strain on cell mechanics is of great relevance for a variety of cell types like endothelial cells in the lung, in arteries or on the bladder, but is not well understood on the cellular and subcellular level. For the detailed analysis of the cellular mechano-response to stretch, we present here a self developed cell stretching device combined with an atomic force microscope.

[1] Engler, A. J., Sen, S., Sweeney, H. L., and Discher, D. E. (2006). Matrix Elasticity Directs Stem Cell Lineage Specification. Cell, 126(4), 677-689.

[2] Suresh, S., Spatz, J., Mills, J. P., Micoulet, A., Dao, M., Lim, C. T., Seufferlein, T. (2005). Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. Acta Biomaterialia, 1(1), 15-30.