Regensburg 2016 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 49: Posters - Cell Mechanics and Migration & Physics of Cancer

BP 49.6: Poster

Mittwoch, 9. März 2016, 17:00–19:00, Poster C

Measuring cell clasticity in PXE- and TMEM43-cells using an Optical Stretcher — •Daniel Helling¹, Jialiang Yu¹, Roland Stange⁴, Jennifer Petersmeyer², Bettina Ibold³, Doris Hendig³, Volker Walhorn¹, Hendrik Milting², and Dario Anselmetti¹ — ¹Experimental Biophysics & Applied Nanoscience, Faculty of Physics, Bielefeld University, 33615 Bielefeld, Germany — ²Herz- und Diabeteszentrum Nordrhein-Westfalen (HDZ NRW) - Universitätsklinikum der Ruhr-Universität Bochum, Erich und Hanna Klessmann-Institut für Kardiovaskuläre Forschung und Entwicklung, 32545 Bad Oeynhausen, Germany — ³Herz- und Diabeteszentrum Nordrhein-Westfalen (HDZ NRW) - Universitätsklinikum der Ruhr-Universität Bochum, Institut für Laboratoriums- und Transfusionsmedizin, 32545 Bad Oeynhausen, Germany — ⁴RS Zelltechnik GmbH, 04103 Leipzig, Germany

We compared the cellular elasticity of fibroblasts provided by patients suffering from PXE (Pseudoxanthoma elasticum) and ARVC (Arrhythmogenic right ventricular cardiomyopathy), respectively. We used an optical stretcher setup with edge detection and automated data analysis, which allows for high cell throughput experiments (>1000 cells per measurement, setup provided by RS Zelltechnik GmbH, Leipzig, Germany). The differences in cell elasticity will be discussed in detail and related to the pathological findings.